Endocrine Abstracts

Introduction: Precocious pubarche is defined as pubic hair onset before age eight in girls and age nine in boys. In 5–20% of cases the cause is late-onset congenital adrenal hyperplasia (LO-CAH), which is due mainly to non-classic 21-hydroxylase deficiency. If not promptly diagnosed, it can lead to accelerated bone maturation, short final height, and in adulthood to severe acne, hirsutism and infertility.Case report: Adolescent male, 15 years-old, h...

Introduction: Primary hyperparathyroidism (PHPT) patients who undergo parathyroidectomy can develop isolated intact parathormone (iPTH) elevation with normal calcemia. Common causes are: renal insufficiency (RI), vitamin D deficit and hypomagnesemia.Aim: To identify clinical factors associated with iPTH elevation in patients submitted to surgery treatment.Methods: The medical records of patients admitted into Santo António&#14...

Hypogonadism occurs in myotonic dystrophy (DM) type 1 and 2, a multisystemic autosomal dominant disorder. DM patients have genetically induced insulin-resistance (IR) and visceral obesity, providing a model to study the impact of metabolic disruptions on hypogonadism. We assessed hypothalamic-pituitary-gonadal function and metabolic features in 22 DM1 and 8 DM2 males (mean±S.D., 46±11years). Hypogonadism, defined as total testosterone (T)<320 ng/dl...

Introduction: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Initial complete surgical resection is crucial. Recurrence is common and primary cause of mortality is severe hypercalcemia.Clinical case: In 2006, a 51 years old male presented with multiple bone pain, anorexia and weight loss, calcium 11.7 mg/dl, PTH 189 pg/ml. Eight years before a diagnosis of atypical parathyroid adenoma was made after left inferior parathyroidectomy ...

Introduction: Hypogonadism occurs in myotonic dystrophy (DM) type 1 and 2, a multisystemic autosomal dominant disorder with insulin resistance and visceral obesity. DM patients provide a model to investigate the impact of metabolic alterations on hypogonadism.Methods: We assessed Leydig and Sertoli cell functions and metabolic features in 32 DM1 (44+11 years),13 DM2 patients (54+9 years) and 32 age and BMI-matched controls.Results:...

Introduction: Thyroid nodules in children and adolescents are less prevalent, but entail greater risk of malignancy than in adults. Most are asymptomatic because they are associated with normal thyroid function, but their prevalence is increasing due to the incidental diagnosis by neck ultrasound.Aims: To evaluate the characteristics of a pediatric population with thyroid nodules submitted to fine-needle aspiration (FNA) biopsy.Met...